Feasibility study of fentanyl with flurbiprofen axetil for postoperative patient controlled intravenous analgesia in patients underwent resection of esophageal carcinoma

Objective: To evaluate the efficacy and safety of flurbiprofen axetil combining with fentanyl for postoperative patient controlled intravenous analgesia(PCIA)in patients underwent resection of esophageal carcinoma.Methods:Forty ASA classⅠ～Ⅱ patients were equally randomly divided into two groups: group A(fentanyl 1.0 mg+droperidol 2.5 mg),group B(fentanyl 0.5 mg+flurbiprofenaxetil 50 mg +droperidol 2.5 mg),and group B was additionally intravenous injection of flurbiprofen axtil 50 mg prior to the surgery.The VAS score,Ramsay sedation scale,PCIA pressing times and the adverse effects were recorded at 1,2,4,8,12,24,36,48 hours after surgery.Results:Patients in the two analgesic groups did not show any significant difference in the VAS scores and PCIA pressing times(P0.05).Ramsay sedation scale,the incidence rate of adverse events such as nausea and vomiting in group A were significantly higher than those in group B.Conclusion: Co-administration of fentanyl with flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following esophageal carcinoma surgery.