2005•Journal of Nanhua UniversityRequires access
Relationship of the S100A2 Protein and Differentiation of Gastric Carcinoma
Gang Xu
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Abstract
Objective To investigate the expression of S100A2 protein and analyze its relationship between differentiation of gastric carcinoma. Methods The expression of S100A2 protein was detected with streptavidin-peroxidase conjugated (S-P) immunohistochemical technique method in 40 cases of gastric carcinoma and normal gastric mucosa. Results The positive rates of S100A2 protein expression were 52.50% in gastric carcinoma and 100% in normal gastric mucosa respectively. The positive rate of S100A2 protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa (P0.05). The positive rate of S100A2 expression were 75.00% in highly, 53.84% in moderately and 18.18% in poorly differentiated gastric carcinoma respectively, which indicated the expression of S100A2 protein was related to the degree of differentiation of gastric carcinoma. Conclusions The loss expression of S100A2 protein was in gastric carcinoma. The positive rate of S100A2 protein expression in poorly differentiation of gastric carcinoma was lower than that in highly and moderately differentiated gastric carcinoma, which indicated that the loss of expression of S100A2 protein was related to the carcinogenesis and differentiation of gastric carcinoma. S100A2 gene might play an important role in carcinogenesis of gastric carcinoma.