Observation of Finasteride and Doxazosin in Treatment of Men with Benign Prostatic Hyperplasia

Objective:To determine the effect of receiving combination of doxazosin and finasteride in treatment of men with lower urinary tract symptoms and with enlarged prostates.Methods:80 patients with a prostate size over 30 g and international prostate symptom score over 15 were divided A and B groups.A group with finasteride 5 mg daily and doxazosin 4 mg 3 months;B groups with finasteride 5 mg daily and doxazosin 4 mg 6 months.Evaluated the changes of IPSS,Qmax,post-void residual volume 1 month after stopping doxazosin.Results:In both group A and B,IPSS,Qmax and post-void residual volume improved significantly in 4 months(P0.05),then,there was no more significantly changes in 7 months(P0.05).And compared group A and B,there was no significantly changes in IPSS,Qmax and post-void residual volume.Conclusion:Patients with lower urinary tract symptoms and moderately enlarged prostates initially receiving combination therapy with finasteride and an alpha-blocker for 3 months are likely to experience no significant symptom of deterioration after stopping doxazosin.