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2010•International Journal of StomatologyRequires access

Effect of signal transducer and activator of transcription 3 in neoplasms invasion and metastasis

Hongzhang Huang

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Abstract

Signal transducer and activator of transcription 3(STAT3) is constitutively activated in many human cancers which has been recognized as one of the common pathways. Numerous cytokines,growth factors,and oncogenic proteins activate STAT3. STAT3 signaling affects the expression and function of a variety of genes that are critical to cell survival,cell proliferation,invasion,angiogenesis. So,regulating the STAT3 signaling pathway constitutes a potential preventive and therapeutic target for cancer metastasis.

About this research paper

What this paper is about

Signal transducer and activator of transcription 3(STAT3) is constitutively activated in many human cancers which has been recognized as one of the common pathways. Numerous cytokines,growth factors,and oncogenic proteins activate STAT3. STAT3 signaling affects the expression and function of a variety of genes that are critical to cell survival,cell proliferation,invasion,angiogenesis. So,regulating the STAT3 signaling pathway constitutes a potential preventive and therapeutic target for cancer metastasis.

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Available abstract

Signal transducer and activator of transcription 3(STAT3) is constitutively activated in many human cancers which has been recognized as one of the common pathways. Numerous cytokines,growth factors,and oncogenic proteins activate STAT3. STAT3 signaling affects the expression and function of a variety of genes that are critical to cell survival,cell proliferation,invasion,angiogenesis. So,regulating the STAT3 signaling pathway constitutes a potential preventive and therapeutic target for cancer metastasis.

Key concepts: STAT3, STAT protein, Metastasis, Cancer research, Angiogenesis, Activator (genetics), Signal transduction, Transcription factor

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