Effect of NAC on serum and lung tissue MDA in model of silica-exposed rats

[Objective]To investigate the effect of N-acetylcysteine(NAC) on serum and lung tissue MDA in model of silica-exposed rats with pulmonary fibrosis.[Methods]A total of 90 male rats were randomly categorized into silica-exposed group(3 group),Dust exposure group: the silicosis model was established via intratracheal instillation of sterile SiO2 dust suspension by non-exposed tracheal injection method;the dust exposure was repeated after 4 weeks.N-acetylcysteine treated group(N group) and control group(C group).Except the C group,other rats received instilling SiO2.S group was fed on NAC [500 mg/(kg ·d)] one week before silica exposure.C group was instilled by normal saline instead of SiO2.All the rats in each group were sacrificed at the 8th week of experiment.Histopathological examination was performed,the level of MDA in serum and lung tissue was observed.[Results]The level of MDA in serum and lung tissue of S group was significantly higher than that of C group(P0.01).The level of MDA of N group was significantly lower than that of S group(P0.01).[Conclusion]The MDA generation in rat with SiO2-induced pulmonary fibrosis can be reduced by NAC which can inhibit the development of lung fibrosis and can reduce lung tissue damage.