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2004•Journal of Regional Anatomy and Operative SurgeryRequires access

Expression of GSTP1 in tissues of different prostatic diseases and its significance

GU Jiu-li

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Abstract

Objective To explore the expression of glutathione S-transferase P1(GSTP1) in tissues of different types of prostatic diseases. Methods A total of 100 specimens of prostatic tissues confirmed definitely were divided into 5 groups (20 specimens in each group): normal prostate (NP), benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HPIN), prostatic incidental carcinoma (PIC), and prostate carcinoma (PC). The expression of GSTP1 in each group was detected by S-P immunohistochemistry. Results The expression of GSTP1 showed a declining tendency in NP, BPH, HPIN, PIC, and PC in order. There was significant difference in expression of GSTP1 between BPH and HPIN, and between HPIN and PIC (P0.01). Conclusion The expression of GSTP1 may be closely correlated with the genesis and progress of prostate carcinoma.

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What this paper is about

Objective To explore the expression of glutathione S-transferase P1(GSTP1) in tissues of different types of prostatic diseases. Methods A total of 100 specimens of prostatic tissues confirmed definitely were divided into 5 groups (20 specimens in each group): normal prostate (NP), benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HPIN), prostatic incidental carcinoma (PIC), and prostate carcinoma (PC). The expression of GSTP1 in each group was detected by S-P immunohistochemistry. Results The expression of GSTP1 showed a declining tendency in NP, BPH, HPIN, PIC, and PC in order. There was significant difference in expression of GSTP1 between BPH and HPIN, and between HPIN and PIC (P0.01). Conclusion The expression of GSTP1 may be closely correlated with the genesis and progress of prostate carcinoma.

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Available abstract

Objective To explore the expression of glutathione S-transferase P1(GSTP1) in tissues of different types of prostatic diseases. Methods A total of 100 specimens of prostatic tissues confirmed definitely were divided into 5 groups (20 specimens in each group): normal prostate (NP), benign prostate hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HPIN), prostatic incidental carcinoma (PIC), and prostate carcinoma (PC). The expression of GSTP1 in each group was detected by S-P immunohistochemistry. Results The expression of GSTP1 showed a declining tendency in NP, BPH, HPIN, PIC, and PC in order. There was significant difference in expression of GSTP1 between BPH and HPIN, and between HPIN and PIC (P0.01). Conclusion The expression of GSTP1 may be closely correlated with the genesis and progress of prostate carcinoma.

Key concepts: GSTP1, Medicine, Prostate, Intraepithelial neoplasia, Hyperplasia, Immunohistochemistry, Prostatic Diseases, Carcinoma

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