Research on Relationship between Lipoprotein Lipase and Metabolic Syndrone

Metabolic syndrome is a complex metabolic disorder syndrome,including obesity,high blood sugar,blood pressure,blood lipid disorders.Lipoprotein lipase(LPL) is one of the key enzymes in lipid metabolism,the main catalyze of chylomicrons and very low-density lipoprotein hydrolysis into triglycerides.Research showed that LPL deficiency and gene mutations cause lipodystrophy.Dfferent gene polymorphisms have a different impact on lipid metabolism,Hind Ⅲ and Pvu Ⅱ mutations cause lipid metabolism,and the S447X polymorphism may have a beneficial lipid changes.LPL is associated with the incidence of metabolic syndrome including obesity,insulin resistance,type 2 diabetes etc.