2017•Int J Cerebrovasc DisRequires access

Lipoprotein lipase gene polymorphisms and atherosclerosis

Xin Chen, Xu Yun

Abstract

Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of the triglyceride core of circulating triglyceride-rich lipoproteins. LPL can not only affect the lipoprotein level, but also play an important role in the development of atherosclerosis. LPL gene polymorphisms may affect LPL activity, and therefore have both pro- and anti-atherogenic effects. This article reviews the relationship between LPL gene polymorphism and atherosclerosis. Key words: Atherosclerosis; Lipoprotein Lipase; Polymorphism, Genetic; Risk Factors

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Key concepts: Lipoprotein lipase, Lipase, Triglyceride, Lipoprotein, Internal medicine, Endocrinology, Polymorphism (computer science), Gene