Clinical study on efficacy and security of lispro in the intensive insulin therapy of elderly diabetic patients

Objective To study the efficacy and adverse reaction of lispro in the intensive insulin therapy of elderly diabetic patients.Methods 66 elderly diabetic patients(≥65 years)were randomly divided into lispro group(insulin pump,22 cases),lispro+humulin N group(22 cases)and humulin R+humulin N group(22 cases)to receive intensive insulin therapy for 2 weeks.The time of reaching standard glucose control,glucose level,the total doses of insulin and the rate of hypoglycemia were compared among 3 groups.Results After the treatment,2 groups used lispro had better postprandial glucose(P0.05),less time of reaching standard glucose control(P0.05)and less doses of insulin(P0.05).There was no significant difference between lispro group and lispro+humulin N group(P0.05).However,the rate of hypoglycemia among 3 groups had no significant difference(P0.05).Conclusion Lispro is an effective and safe drug for intensive insulin therapy of elderly diabetic patients.