Effects of ruanganning against liver fibrosis in rats

Objective To study the effects of ruanganning(a compound of Chinese medicine) on liver fibrosis induced by carbon tetrachloride(CCl4) in rats. Methods Sixty male Wister rats were randomly divided into six groups with 10 rats each.The rat models of hepatofibrosis were produced by subcutaneous injection of CCl4 in 50 rats,which were equally divided into 5 groups of MC(model control),R1(treated with ruanganning 0.12 g/kg),R2(treated with ruanganning 0.06 g/kg),R3(treated with ruanganning 0.03 g/kg) and PC(treated with colchicines as positive control medicine).The rest 10 rats were taken as blank controls(group BC).Six weeks later,serum levels of ALT,AST,TP,ALB,and Hyp and the activities of SOD and MDA in the liver were detected and the liver specimen was examined pathologically. Results The levels of ALT,AST,MDA and Hyp were higher,but those of SOD,Tp and ALB were lower,in group MC than those in group BC(P0.05 or P0.01). The levels of ALT,AST,MDA and Hyp were lower,but those of SOD,Tp and ALB were higher,in groups of R1 and R2 than those in group MC(P0.01 or P0.05).Pathologically,the severity of liver damage was slighter in groups of R1 and R2 than that in group MC. ConclusionRuanganning is capable of inhibiting hepatofibrosis in rats model.