Observation of metoprolol and captopril in treatment of chronic congestive heart failure in plateau regions

Objective To observe the efficacy of using metoprolol combined with captopril in treatment of chronic conges tive heart failure (CHF) in plateau regions.Methods Forty patients were chosen as subjects.With heart function at grade (NYHA) 2-4,they were suffered from left ventricular enlargement,left ventricular end-systolic volume increase as well as LVEF ≤40%,and had history of basic heart disease,with or without symptoms such as difficulty in breathing,lack of strength,and fluid retention (edema).The subjects were randomized into treatment group and control group.Small doses of digitalis,diuretic,and vascular dilation drugs were used on the control group,while small doses of metoprolol and captopril in addition to those given to the control group were administered on the treatment group.A comparison was made 6 months later.Results Patients in the treatment group showed significant differences in the results of left ventricular end-diastolic diameter (LVEDD),left ventricular ejection fraction (LVEF),and 6-minute walking test (6-MWT) (P 0.05).Conclusion Combining metoprolol and captopril with traditional therapies on heart failure in plateau regions has significant efficacy.