Expression and significance of E-CD and CD44V6 in esophageal squamous cell carcinoma

objective To investigate the expression of E CD and CD44V6 and their clinical significance in patients with esophageal squamous cell carcinoma.Methods E CD and CD44V6 expressions were determined in paraffin embedded tissues from 58 cases with esophageal squamous cell carcinoma by immunohistochemical methods. Forty two cases were followed up for 3 years.Results Low expression of E CD and over expression of CD44V6 were closely related with the invasion,metastasis,recurrence and prognosis of esophageal squamous cell carcinoma ( P 0.05).The correlation was observed between low E CD expression and cellular differentiation ( P 0.05).No significant correlation was found between E CD expression and CD44V6 expression in these patients ( P 0.05).Conclusions The expressions of E CD and CD44V6 correlate with the development,invasion,metastasis and prognosis of esophageal squamous cell carcinoma.No correlation of E CD and CD44V6 expression is demonstrated in esophageal squamous cell carcinoma,suggesting that as independent function regulating factors in esophageal squamous cell carcinoma E CD and CD44V6 can be regarded as important signs of invasion?metastasis and prognosis.