Drug Resistance Analysis on ESBLs-producing Gram-negative Bacilli to 12 Kinds of Antibacterial Drugs

OBJECTIVE To analyze the antibiotic resistance of ESBLs-producing Gram-negative bacilli to 12 kinds of antibacterial drugs. METHODS A total of 204 isolates from clinical specimens were screened for the presence of ESBLs by the VITEK ESBLs detection test and the double-disk synergy tests. In vitro antibacterial activity of 12 kinds of antibacterial drugs to ESBLs-producing Gram-negative bacilli were compared. RESULTS The detection rate of ESBLs was 23%. Of all ESBLs-producing bacilli,the productive rate of multi-resistant bacilli was 87.5%. Imipenem and meropenem had the most powerful antibacterial activity. Cefepime had weaker activity to ESBLs-producing bacilli. Cefoxitin, ofloxacin and aminoglycosides had powerful activity to ESBLs-producing Klebsiella pneumoniae. Piperacillin/tazobactam showed better activity to ESBLs-producing K. pneumoniae and Pseudomonas aeruginosa. CONCLUSIONS Carbapenem could be of the first choice to treat the infection caused by ESBLs-producing Gram-negative bacilli.