Clinical observation of microwave ablation combined with portal vein perfusion chemotherapy in the treatment of hepatocellular carcinoma combined with portal vein tumor thrombus

Objective To investigate the therapeutic effects of percutaneous microwave ablation under ultrasound guidance combined with portal vein perfusion chemotherapy in the treatment of hepatocellular carcinoma(HCC) combined with portal vein tumor thrombus(PVTT).Methods 59 cases of patients with HCC and PVTT in the main trunk or the first branch of portal vein were randomly divided into two groups.30 cases in the observation group were treated with microwave ablation and PVTT.29 cases in the control group were treated with microwave ablation alone.The contrast-enhanced ultrasound(CEUS),serum fetoprotein(AFP),portal vein tumor thrombus were detected,and the curative effects and survival rates of the two groups were compared.Results The 0.5,1,2,3 years recurrence rates of the observation group were significantly lower than those of the control group(P 0.05).The PVTT minification rate and the AFP negative rate of the observavation group were significantly higher than those of the control group(P 0.05).The 0.5,1,2,3 years survival rate of the observation group were significantly higher than those of the control group,the differences were statistically significant(P 0.05).Conclusion Percutaneous microwave ablation under ultrasound guidance combined with portal vein perfusion chemotherapy can improve the curative effect of HCC combined with PVTT and increase patients' survival rate,which is a valuable microinvasive method.