Association of rs2108622 polymorphism of CYP4F2 gene and essential hypertension in the Northern Han Chinese

Objective:This study was designed to investigate the potential association rs2108622 polymorphism of CYP4F2 gene and essential hypertension in the Northern Han Chinese.Methods: 765 essential hypertensive patients(HT group) and 477 healthy normotensive controls(NT group) were screened and DNA was acquired from white blood cells.Real-Time quantitative PCR was used for the detection of rs2108622 polymorphism of CYP4F2 gene.Results: The genotype distribution and allele frequency of rs2108622 polymorphism were not significantly different between HT group and NT group,AA: AG: GG=8.0%/7.4%: 38.9%/34.5%: 53.0%/ 58.1% for the genotype distribution frequency and A: G=27.5%/24.7%: 72.5%/75.3% for allele frequency.After adjustment for potential confounding factors,such as age,BMI,smoking and alcohol status,no significant association has been found between rs2108622 polymorphism and hypertension in all genetic models(allele comparison: OR=1.147,95% CI=0.853-1.543;dominant genetic model: OR=0.788,95% CI=0.549-1.131;recessive genetic model: OR=1.153,95% CI=0.549-2.422;homozygote comparison: OR=1.018,95% CI=0.48-2.157;additive genetic model: OR=0.872,95% CI=0.649-1.172).Subgroup analyses were performed by gender and showed that A allele of rs2108622 polymorphism has an increased trend in male HT group,but the difference did not reach statistical significance.Conclusion: Our research demonstrated that rs2108622 of CYP4F2 gene was associated with essential hypertension in Northern Chinese Han population.