Effects of Ornithine-aspartate Combined with Xingnaojing Injection on Hepatic Encephalopathy in Patients with Liver Cirrhosis

Objective To observe the clinical effcacy of ornithine-aspartate combined with xingnaojing injection on hepatic encephalopathy(HE) in patients with liver cirrhosis.Methods 64 cases with HE were randomly divided into control group(n=32) and observation group(n=32).All patients were given no-protein diet,protecting liver,anti-infection and keeping water and electrolye in balance and so on,based on the conventional routine treatment the control group plus aceglutamide 1g/d,the observation group plus ornithine-aspartate 7.5 g/d and xingnaojing injection 20 ml/d.The course of treatment was 10 days.The therapeutic efficiency,serum ammonia and liver function of two groups were compared.Results The excellence rate and total effective rate of observation group were significantly higher than those of control group(all P0.05,50.0%,93.8% vs 31.2%,81.2%).The time of mind consciousness and NCT in observation group were significantly shorter than those in the control group(all P0.001),the level of serum ammonia and TBIL were significantly decreased than those in the control group(P0.05).Conclusion Ornithine-aspartate combined with xingnaojing injection treating HE in patients with liver cirrhosis are effective in down-regulating serum ammonia,decurtating consciousness time and increasing the clinical efficacy,it has the value for clinical use.