Toxicologic Study on Qishen Fukang Capsules

Objective:To observe the acute toxicity Qishen Fukang Capsule in mice and its long-period toxicity in rats,so evaluated the safety dosage window in clinical application.Methods:The maximal tolerance dosage was tested by gastric perf usion of single oral dose of Qishen Fukang Capsule.Three groups of rats(in high,moderate and low dosage of Qishen Fukang Capsule)were administered with repeated gastric perf usion of Qishen Fukang Capsule for 26 weeks.Body weight,hematological and hema to2 biochemical parameters,coefficient and histomorp hological figure oforgans were examined in 13,26 weeks and 4 weeks after t he cessation of Qishen Fukang Capsule.Results:The oral maximal tolerance dose of Qishenfukang Capsule in mice was more than 39g/kg.There was no significant difference between the testgroups and the control in all tested parameters.Conclusion:The Qishen Fukang Capsule have no obviously toxicity,so suggest that Qishenfukang Capsule is safe for clinical application.