The Correlation of 16-Slice Spiral CT Perfusion Imaging with Angiogenesis in Solitary Pulmonary Lesion

Objective To evaluate the correlation of CT perfusion imaging(CTPI) parameters with microvessel density(MVD)and vascular endothelial growth factor(VEGF) in solitary pulmonary lesion using 16-slice spiral CT.Materials and Methods 52 patients with solitary pulmonary lesion received 16-slice spiral CT perfusion scanning.Perfusion parameters including blood flow(BF),relative blood volume(rBV),permeability(Pm),and time of top peak(TTP) were created by body-perfusion software.The expressions of CD34 and VEGF in 39 cases who had operation were detected by LSAB immunohistochemistry staining,then the MVD counting and the expressions of VEGF were recorded.Results BF,rBV and Pm of malignant and the inflammatory groups were higher than those of the benign group(P0.05).No statistically significant differences in BF and rBV were found between the malignant and the inflammatory(P0.05),but Pm of the malignant group was higher than that of the inflammatory group(P0.05).TTP of the benign group was higher than that of the malignant and the inflammatory group,but there was no statistically difference in TTP between the malignant and the inflammatory or between the inflammatory and the benign(P0.05).MVD and VEGF of the malignant and the inflammatory groups were higher than that of the benign group(P0.05),while no statistically significant difference was found between the malignant and the inflammatory(P0.05).rBV,BF and Pm was positively correlated with MVD and VEGF(P0.05) in each group,but TTP were not related to MVD and VEGF(P0.05).Conclusion MSCT perfusion parameters have strong positive correlation with angiogensis in SPN and provide quantitative functional information about solitary pulmonary lesion,which are helpful for the differential diagnosis of solitary pulmonary lesion.