Catalytic Synthesis of Ethyl Chloroacetate with Sodium Bisulfate

Sodium bisulfate can be used as catalyst for the esterification instead sulphuric acid. The optimum condition have been studied on which the chloroacetatic acid and ethyl alcohol are esterified into ethyl chloroacetate in the presence of the sodium bisulfate monohydrate catalyst. The yield of ester could reach 73. 0%, under amount of substance ratio of chloroacetatic acid, ethyl alcohol and sodium bisulfate were 1: 3. 5: 0. 036, cycolhexane as soluvent, refluxing and water segrating for 100 min.