ScholarLens Back to search
2011•Qilu yixue zazhiRequires access

EXPRESSIONS OF CXCL12 AND CXCR4 IN TRIPLE-NEGATIVE BREAST CANCER AND THEIR SIGNIFICANCE

Zhuying Wei

Open publisher page 0 citations

Abstract

Objective To investigate the expressions of chemokine CXCL12 and its receptor CXCR4 in triple-negative breast cancer(TNBC) and their clinicopathologic significance. Methods The expressions of CXCL12 and CXCR4 were detected immunohistochemically by SP method in 55 cases of TNBC.The corresponding clinicopathologic parameters(patient's age,tumor size,lymph node metastasis,clinical stage) were observed and analyzed. Results The expressions of CXCL12 and CXCR4 were not related to the age,tumor size and clinicopathologic stage(P0.05),but positively related to the axillary lymph node metastasis(r=0.413,0.325;P0.05).The expression rates of CXCL12 and CXCR4 were higher in those with lymph node metastasis than that without(uc=3.02,2.38;P0.05). Conclusion It seems that chemokine CXCL12 and its receptor CXCR4 can be served as important molecular markers for predicting axillary lymph node metastasis and prognosis of TNBC.

About this research paper

What this paper is about

Objective To investigate the expressions of chemokine CXCL12 and its receptor CXCR4 in triple-negative breast cancer(TNBC) and their clinicopathologic significance. Methods The expressions of CXCL12 and CXCR4 were detected immunohistochemically by SP method in 55 cases of TNBC.The corresponding clinicopathologic parameters(patient's age,tumor size,lymph node metastasis,clinical stage) were observed and analyzed. Results The expressions of CXCL12 and CXCR4 were not related to the age,tumor size and clinicopathologic stage(P0.05),but positively related to the axillary lymph node metastasis(r=0.413,0.325;P0.05).The expression rates of CXCL12 and CXCR4 were higher in those with lymph node metastasis than that without(uc=3.02,2.38;P0.05). Conclusion It seems that chemokine CXCL12 and its receptor CXCR4 can be served as important molecular markers for predicting axillary lymph node metastasis and prognosis of TNBC.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the expressions of chemokine CXCL12 and its receptor CXCR4 in triple-negative breast cancer(TNBC) and their clinicopathologic significance. Methods The expressions of CXCL12 and CXCR4 were detected immunohistochemically by SP method in 55 cases of TNBC.The corresponding clinicopathologic parameters(patient's age,tumor size,lymph node metastasis,clinical stage) were observed and analyzed. Results The expressions of CXCL12 and CXCR4 were not related to the age,tumor size and clinicopathologic stage(P0.05),but positively related to the axillary lymph node metastasis(r=0.413,0.325;P0.05).The expression rates of CXCL12 and CXCR4 were higher in those with lymph node metastasis than that without(uc=3.02,2.38;P0.05). Conclusion It seems that chemokine CXCL12 and its receptor CXCR4 can be served as important molecular markers for predicting axillary lymph node metastasis and prognosis of TNBC.

Key concepts: CXCR4, Medicine, Breast cancer, Stage (stratigraphy), Lymph node, Clinical significance, Triple-negative breast cancer, Metastasis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
EXPRESSIONS OF CXCL12 AND CXCR4 IN TRIPLE-NEGATIVE BREAST CANCER AND THEIR SIGNIFICANCE — Research Paper | ScholarLens