The determination and its clinical significance of serum acute phase protein in patients with depression

Objective To investigate the clinical significance of serum high sensitive C reactive protein(hs-CRP),albumin(Alb),prealbumin(PA) and transferrin(TF) levels for the diagnosis of patients with depression.Methods The 60 patients with depression and 40 healthy subjects were enrolled,and their serum levels of Alb were determined by bromcresol green.The levels of hs-CRP,PA and TF were determined by immunoturbidimetry.Results The serum hs-CRP level in depression group [(5.12±2.07) mg/L] was significantly higher than that in the control group [(1.88±1.29) mg/L,P0.01].The levels of serum Alb [(42.6±4.2) g/L],PA [(244±48) mg/L] and TF [(1.98±0.42) g/L] in the depression group were significantly lower than those in the control group [(46.1±4.6) g/L,(293±52) mg/L and(2.46±0.39) g/L,P0.01].The Pearson analysis Hamilton depression scale(HAMD) showed a significant positive correlation with hs-CRP(r=0.592,P0.01),but there was a significantly negative correlation with serum Alb,PA and TF(r=-0.463,-0.525 and-0.491,P0.01).Conclusions The acute phase protein level(APP) of depression patients is abnormal.It has an important clinical significance in the diagnosis and treatment of depression by determining the levels of serum hs-CRP,Alb,PA and TF.