ScholarLens Back to search
2006•Journal of Southeast UniversityRequires access

Effect of Sanshengyin on expression of Bcl-2 and Bax protein in rat hippocampus after focal cerebral ischemia

Changsong Wang, Yuanyuan Wang, Jin Guangrong

Open publisher page 0 citations

Abstract

Objective To study the effect of Sanshengyin on expression of Bcl-2 and Bax protein in rat hippocampus after focal cerebral ischemia.Method Rat model of middle cerebral artery occlusion(MCAO) and reperfusion was established.By means of SP immunohistochemistry,cells with positive expression of Bcl-2 and Bax protein in hippocampus were analyzed at 3,6,12,24 h and 3 d after reperfusion.Result In Sanshengyin group,Bcl-2 protein positive cells increased more and lasted longer than that in MCAO group,in different hippocampus districts of ischemia side,Bcl-2/Bax were different;while Bax protein positive cells of two groups had no significant differences.Conclusion Although Sanshengyin increases the expression of Bcl-2 and the ratio of Bcl-2/Bax,it doesn't stop the aptosis of neurons in hippocampus after focal cerebral ischemia.

About this research paper

What this paper is about

Objective To study the effect of Sanshengyin on expression of Bcl-2 and Bax protein in rat hippocampus after focal cerebral ischemia.Method Rat model of middle cerebral artery occlusion(MCAO) and reperfusion was established.By means of SP immunohistochemistry,cells with positive expression of Bcl-2 and Bax protein in hippocampus were analyzed at 3,6,12,24 h and 3 d after reperfusion.Result In Sanshengyin group,Bcl-2 protein positive cells increased more and lasted longer than that in MCAO group,in different hippocampus districts of ischemia side,Bcl-2/Bax were different;while Bax protein positive cells of two groups had no significant differences.Conclusion Although Sanshengyin increases the expression of Bcl-2 and the ratio of Bcl-2/Bax,it doesn't stop the aptosis of neurons in hippocampus after focal cerebral ischemia.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect of Sanshengyin on expression of Bcl-2 and Bax protein in rat hippocampus after focal cerebral ischemia.Method Rat model of middle cerebral artery occlusion(MCAO) and reperfusion was established.By means of SP immunohistochemistry,cells with positive expression of Bcl-2 and Bax protein in hippocampus were analyzed at 3,6,12,24 h and 3 d after reperfusion.Result In Sanshengyin group,Bcl-2 protein positive cells increased more and lasted longer than that in MCAO group,in different hippocampus districts of ischemia side,Bcl-2/Bax were different;while Bax protein positive cells of two groups had no significant differences.Conclusion Although Sanshengyin increases the expression of Bcl-2 and the ratio of Bcl-2/Bax,it doesn't stop the aptosis of neurons in hippocampus after focal cerebral ischemia.

Key concepts: Hippocampus, Immunohistochemistry, Ischemia, Apoptosis, BAX Protein, Protein expression, Middle cerebral artery, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Sanshengyin on expression of Bcl-2 and Bax protein in rat hippocampus after focal cerebral ischemia — Research Paper | ScholarLens