Regressing left ventricular hypertrophy by captopril in rat with pressure overload

Objective To observe the effects of captopril on regressing left ventricular hypertrophy in rat with pressure overload.Methods The model of left ventricular hypertrophy in rat with pressure overload by abdominal aortic constriction was used.36 SD male rats were randomly divided into 3 groups: sham operation group,model group and captopril group.After treatment 4 weeks,it was observed that the changes of myocardial hypertrophy [left ventricular mass index(LVMI),left ventricular myocardium HE staining,left ventricular myocytes ultramicrostructure].Results LVMI in model group(2.32±0.35) was increased significantly than that in sham operation group(P0.01).LVMI in captopril group was lower than that in model group(2.98±0.36)(P0.01).The changes of left ventricular myocardium HE staining and left ventricular myocytes ultramicrostructure were consistent with those of LVMI.Conclusion Captopril had the effect on regressing left ventricular hypertrophy.