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2009•Zhongguo yaofangRequires access

Effect of Bicyclol on Pharmacokinetics of Rifampin in Rats

Di Wu

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Abstract

OBJECTIVE: To study the effect of bicyclol on serum concentration and pharmacokinetics of rifampin in rats.METHODS: Twelve Wistar rats were assigned to receive rifampin 63.4 mg·kg-1 alone(control group)or in combination with bicyclol 15.85 mg·kg-1(trial group) q.d for 4 days.Plasma samples were obtained on day 4 before and after drug administration 0.25,0.5,1,1.5,2,4,6,8,12 and 24 h.Blood concentrations of rifampin of 2 groups were determined by HPLC and the pharmacokinetics parameters were evaluated as well.RESULTS: Rifampin showed no significant differences at different time point in its concentration and pharmacokinetic parameters(P0.05) between in 2 groups.CONCLUSION: Used in combination with rifampin,bicyclol showed insignificant effect on the pharmacokinetics of rifampin in rats.

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OBJECTIVE: To study the effect of bicyclol on serum concentration and pharmacokinetics of rifampin in rats.METHODS: Twelve Wistar rats were assigned to receive rifampin 63.4 mg·kg-1 alone(control group)or in combination with bicyclol 15.85 mg·kg-1(trial group) q.d for 4 days.Plasma samples were obtained on day 4 before and after drug administration 0.25,0.5,1,1.5,2,4,6,8,12 and 24 h.Blood concentrations of rifampin of 2 groups were determined by HPLC and the pharmacokinetics parameters were evaluated as well.RESULTS: Rifampin showed no significant differences at different time point in its concentration and pharmacokinetic parameters(P0.05) between in 2 groups.CONCLUSION: Used in combination with rifampin,bicyclol showed insignificant effect on the pharmacokinetics of rifampin in rats.

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Available abstract

OBJECTIVE: To study the effect of bicyclol on serum concentration and pharmacokinetics of rifampin in rats.METHODS: Twelve Wistar rats were assigned to receive rifampin 63.4 mg·kg-1 alone(control group)or in combination with bicyclol 15.85 mg·kg-1(trial group) q.d for 4 days.Plasma samples were obtained on day 4 before and after drug administration 0.25,0.5,1,1.5,2,4,6,8,12 and 24 h.Blood concentrations of rifampin of 2 groups were determined by HPLC and the pharmacokinetics parameters were evaluated as well.RESULTS: Rifampin showed no significant differences at different time point in its concentration and pharmacokinetic parameters(P0.05) between in 2 groups.CONCLUSION: Used in combination with rifampin,bicyclol showed insignificant effect on the pharmacokinetics of rifampin in rats.

Key concepts: Pharmacokinetics, Pharmacology, Rifampicin, High-performance liquid chromatography, Plasma concentration, Chemistry, Medicine, Antibiotics

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