Evaluation of treatment of degenerative lumbar spondylolisthesis with allogeneic bone graft

Objective:To evaluate the effect of treatment of degenerative lumbar spondylolisthesis with allogeneic bone graft. Methods:Forty patients with degenerative lumbar spondylolisthesis were treated using bone allograft of freeze-dried irradiation sterilization (group A),and was compared with 37 patients with degenerative lumbar spondylolisthesis treated at the same period using intervertebral fusion cage system and internal fixation (group B),the effects were evaluated accoding to clinical observation and X-ray examination. Results:Four patients in group A and 3 patients in group B had superficial wound complications,8 patients in group A and 4 patients in group B with slight higher body temperature after operation,and the differences between the two groups were not significant (P0.05). According to 12 ~ 36 months follow-up,the very good and good rate in group A and B was 88.45% and 86.5% respectively,and the difference between the two groups was not significant (P0.05). Bone healing time of patients in group A was 5 months by average,bone fusion rate was 100%; the grafted bones were absorbed at the end of 12th months. According to postoperative X-ray film and the final follow-up X-ray film,the relative average loss of vertebral height were 12.3% and 11.9% in patients of group A and B respectively,and the difference between the two groups was not significant (P0.05). Conclusion:Treatment of degenerative lumbar spondylolisthesis using bone allograft of freeze-dried irradiation sterilization has satisfactory effect,high interbody fusion rate,maintenance of intervertebral space height,and no significant immune rejection.