Epidural anesthesia and sedation effect of dexmedetomidine combined with propofol

Objective To observe and analyze the epidural anesthesia and sedation effect of dexmedetomidine combined with propofol. Methods The clinical data of 98 patients underwent epidural anesthesia in the municipal hospital of Suzhou from June2012 to December 2014 were retrospectively analyzed. Fourty nine patients with epidural anesthesia by dexmedetomidine were dexmedetomidine group,and another 49 patients with epidural anesthesia by dexmedetomidine and propofol were combination group. Sedation onset time and wake time of the two groups were counted and analyzed. Ramsay sedation score and MAP and HR situation at before anesthesia( T0),to maintain anesthesia 5 min( T1),anesthesia 30 min( T2),end of operation( T3) of the two groups were observed. The adverse reactions during and after the operation were recorded. Results Sedation onset time and wake time of the combination group were significantly shorter than those of the dexmedetomidine group( P 0. 05). Ramsay sedation scores of the two groups at T0 had no significant difference( P 0. 05),and those at T1,T2 and T3 of the combination group were lower than those of the dexmedetomidine group,which were more close to calm satisfaction scores. MAP( mean arterial pressure) of the two groups at T0 and T1 had no significant difference( P 0. 05). MAP of the combination group at T2 and T3 were significant lower than that of the dexmedetomidine group( P 0. 05). HR( heart rate) of the two groups at T0 and T3 had no significant difference( P 0. 05). HR of the combination group at T1 and T2 were lower than that of the dexmedetomidine group( P 0. 05). The incidence of adverse reactions of the two groups had no significant difference( P 0. 05). Conclusion The sedative effect of epidural anesthesia by dexmedetomidine combined with propofol is better and the adverse reactions are less and it is also safe,waking up quickly and conducive to surgery.