Simultaneous Determination of 20 Phthalates in Leather Products by Microwave-Assisted Extraction Coupled with Gas Chromatography-Tandem Mass Spectrometry

In order to strengthen the supervision of phthalates in leather products,a method for the simultaneous determination of 20 phthalates in leather products was established.Phthalates in leather products were extracted by microwave-assisted extraction(MAE) using acetonitrile as solvent,the extracts were purified by solid-phase extraction,and then analyzed using gas chromatography-tandem mass spectrometry(GC-MS/MS).At the condition of S/N=10,the limits of quantification are 0.2,0.2 and 0.1 mg/kg for DINP,DIDP and DMPP,respectively,while the limits of quantification are all less than 0.05 mg/kg for other phthalates.The spiked average recoveries vary from 87.75% to 94.59%.The relative standard deviation(RSD) of precision experiment is less than 16%.The proposed method was applied to the analysis of commercially available leather products,and phthalates were found to exist in two samples.