Clinical Significance of Alteration of coagulation function in 112 patients with Acute pancreatitis

Objective:To evaluate the changes of blood coagulation and their clinical significance in patients with acute pancreatitis.Methods:One hundred and twelve patients acute pancreatitis were recruited in this study.Patients were divided into two groups,severe acute pancreatitis(48 cases)and mild acute pancreafitis(64 cases),according to the diagllostic criteria set by the Chinese Medical Association in 2004.Plasma coagulation parameters including prothrombin time(PT),activated partial thromlooplastin time(APTT),fibrinogen(FlB)and D-dimmer were redorded.Results :Com-Pared with MAP group,there were significant differences On APTT、PT、FIB and D-dimmer in SAP group.D-dimmer was correlated to the APACHE II score.the morality were higher in patients with SAP patients than those in the MAP patients.Conclusions :Disorders of coagulation and microcirculation disturbances were observed in patients with severe acute pancreatitis.These alterations may be useful in the assessment of the disease severity and prognosis of patients with acute pancreatitis.