Clinical comparative observation of mirtazapine and sertraline in the treatment of depression with anxiety

Objective To investigate the clinical efficacy and safety of mirtazapine and sertraline in the treatment of patients of depression with anxiety. Methods 96 patients of depression with anxiety in our hospital were divided into two groups according to different treatment method, each group had 48 cases.The control group were received sertraline treatment, while the observation group were received mirtazapine treatment.The therapeutic effect of two groups were observed. Results There was no significant difference in antidepressant treatment effect between two groups(P0.05).The anxiolytic treatment effect of the observation group was better than that of the control group,and the difference was statistically significant(P 0.05). The decreased level of Hamilton Anxiety Scale score and Depression Scale score after a week of treatment in the observation group were better than those in the control group,and the difference was statistically significant(P 0.05).There was no significant difference in incidence of adverse reactions between two groups(P 0.05). Conclusion The effect of mirtazapine in the treatment of depressive is equivalent to sertraline,but its anxiolytic effect is better than that of the control group,and it has more rapid onset,tolerated adverse reactions,and is worthy of clinical promotion and application.