EXPRESSION OF GST-Π AND P-GP IN COLORECTAL CANCER AND THEIR CLINICAL SIGNIFICANCES

Objective:To study the expression of glutathione-s-transferase-π(GST-π) and P-glycoprotein(P-gp) in human colorectal cancer and their relationships with clinical pathological characteristics of colorectal cancer. Methods:S-P immunohistochemical staining was used to detect the expression of GST-π and P-gp in 86 cases colorectal cancer and 52 cases distal normal tissue(10cm from the cancer). And the correlations between GST-π, P-gp expression and the clinical pathological characteristics of colorectal cancer were analyzed.Results:The positive expression rate of GST-π and P-gp in colorectal cancer were all signif icantly higher than that in distal normal tissues(P 0.01, P 0.05). The expression of P-gp in colorectal cancer was related with lymph node metastasis: the positive expression rate of P-gp of patients with lymph node metastasis was signif icantly higher than that no lymph node metastasis(P 0.05). There had positive correlation between GST-π and P-gp expression in colorectal cancer(P 0.01). Conclusions: High expression of GST-π and P-gp in colorectal cancer may be associated with primary multidrug resistance of the cancer. Joint detection of GST-π and P-gp in clinic can provide theoretical basis for reasonable individual chemotherapy scheme.