Dynamic Changes in Childhood Acute Lymphoblastic Leukemia LDH, SF and ESR

Objective To explore the changes and clinical significances of serum lactic dehydrogenase(LDH)、ferrritin(SF) and erythrocyte sedimentation rate(ESR) in children with acute lymphoblastic leukemia(ALL).Methods Serum LDH、SF and ESR levels were measured and analyzed in 112 children with ALL before chemotherapy、complete remission and after relapse.Observe the correlations among LDH、SF and ESR.Results Serum LDH、SF and ESR levels of children ALL patients before chemotherapy were significantly higher than those of control group and complete remission group(P 0.01).Otherwise complete remission group had no significant difference than those of control group(P0.05).These changes were occurred in relapse group.LDH、SF and ESR were positively correlated in children ALL.Conclusion Making dynamic analysis of serum LDH、SF and ESR levels maybe considered as important indicators for observing disease process、therapeutic effects and prognosis for children with ALL.