The correlation between serum concentrations of apolipoprotein A5 and levels of fasting insulin and adiponectin in patients with coronary heart disease

Objective To explore the change of serum concentrations of apolipoprotein A5(APOA5),and the relationship with levels of adiponectin and fasting insulin(FINS)in patients with coronary heart disease(CHD).Methods Blood lipids,the serum concentrations of APOA5,adiponectin and insulin were examined in 95 individuals,who were divided into two groups:51 patients with CHD and 44 healthy individuals.Results The concentrations of APOA5 and adiponectin in CHD patients were significantly lower than the healthy individuals[(230.06±115.8)μg/L and(3.03±1.85)μg/L vs(324.43±151.79)μg/L and(4.12±2.48)μg/L respectively,all P0.05];whereas insulin levels were significantly higher than the healthy individuals[(9.85±5.94)mU/L vs(7.85±3.04)mU/L respectively,P0.05].Plasma APOA5 was negatively correlated with FINS and triglyceride,but positively correlated with HDL-C;no correlation was found with adiponectin.Conclusion The patients with CHD have decreased serum levels of APOA5 and adiponectin,but increased levels of FINS.APOA5 can influence blood lipids,which may partly attribute to the effects of insulin resistance.