2012•Chinese Journal of Clinical Oncology and RehabilitationRequires access
Relationship between telomerase activity and cervical cancer and cervical intraepithelial neoplasia
Zhang Ding-fu
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Abstract
Objective To study the relationship between telomerase activity and cervical cancer and cervical intraepithelial neoplasia.Method 50 cases infiltrating cervical cancer,152 cases cervical intraepithelial neoplasia(58 cases CINⅢ、44 cases CINⅡ、50 cases CINⅠ)and 66 cases normal control cervical fresh tissue were measured for telomerase activity using TRAP-PCR.Result We detected strong telomerase activity in 42 cervical cancer(84.0%)and telomerase was negative in 8 cases;Telomerase was positive in 33 cases CINⅢ(56.9%),and telomerase was negative in 25 cases;Telomerase was positive in 15 cases CINⅡ(34.1%),and telomerase was negative in 29 cases;Telomerase was positive in 12 cases CINⅠ(24.0%),and telomerase was negative in 38 cases;Only 3 cases of 66 normal control tissue was positive of telomerase activity(P0.01)were significantly greater in cervical cancer and precancerous lesions than in benign lesions and normal control.Conclusion Telomerase activity may play an important role during cervical carcinogenesis.It is asignal for discuss cervical disease advance and cervical carcinogenesis.