Clinical trial of gatifloxacin in the treatment of bacterial infections.

Objective: To evaluate the safety and efficacy of domestic gatifloxacin in the treatment of acute bacterial infections. Methods: A total of 40 patients were treated in this trial. 20 patients enrolled in gatifloxacin group, 20 patients enrolled in levofloxacin group. Results: The overall efficacy rate and cure rate in trial and control group were 94.74% and 90% respectively. The bacterial clearance rates were 94. 12% and 89.47% respectively in two groups. There were no statistical significant differences of the above results between the two groups. MIC values of gatifloxacin had good activities against gram - positive and many gram - negative organisms. The adverse drug raection rates were 10% and 20% in gatifloxacin and levofloxacin group respectively. There were no photosensitivity and other serious adverse effective. Conclusion: The results suggeste that gatifloxacin is an effective and safe new quinolone in treatment of acute bacterial infections.