2003•Unpublished venueRequires access

Effect of selenium on monocyte chemoattractant protein-1 in human umbilical vein endothelial cells

Yanbo Li

Abstract

Objective To observe the effect of selenium on expression of monocyte chemoattractant protein-1 (MCP-1) mRNA in human umbilical vein endothelial cell line ECV-304.Methods Cell line ECV-304 was incubated with high glucose, advanced glycosylation end products (AGE), high insulin and H 2O 2 respectively;simultaneously, the cell line ECV-304 pre-treated with selenium was incubated with above factors, the expression of MCP-1 mRNA was detected and compared.Results Four factors increased the expression of MCP-1 mRNA independently;selenium inhibited the expression of MCP-1 mRNA induced by 4 factors distinctly.Conclusions Selenium repress the expression of MCP-1 mRNA in the cell line ECV-304.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Umbilical vein, Selenium, Monocyte, Messenger RNA, Human umbilical vein endothelial cell, Cell culture, Chemistry, Internal medicine