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2004•Journal of Practical Medical TechniquesRequires access

Effect of Yiqitonglinchongji on Bcl-2、Bax Expression in Rats of ProstaticTissue with BPH

Dongwen Wang

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Abstract

Objective To investigate the mechanism that yiqiyonglinchongji treats benign prostatic hyperlassia. Methods A total of 8 case of BPH, 24 case of BPH influenced by yiqiyonglinchongji and proscar were studied.The apoptosis status was detected by means of Immunohistochemistry. Resulsts The expression of Bcl-2 were higher in model group than that of the group treated by high-dose of yiqiyonglinchongji and proscar(P0.05,P0.01)respectively. The expression of Bax were higher in the group treated by proscar than that of the model group(P0.01). The difference of Bcl-2/Bax in the groups treated by high-dose of yiqiyonglinchongji and treared by proscar were not significant(P0.05). Conclusions Promoting apoptosis was probably the mechanism of yijitonglinchongji treating BPH, Bcl-2 and Bax genes play an important role in the regulation of prostatic apopitosis.

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What this paper is about

Objective To investigate the mechanism that yiqiyonglinchongji treats benign prostatic hyperlassia. Methods A total of 8 case of BPH, 24 case of BPH influenced by yiqiyonglinchongji and proscar were studied.The apoptosis status was detected by means of Immunohistochemistry. Resulsts The expression of Bcl-2 were higher in model group than that of the group treated by high-dose of yiqiyonglinchongji and proscar(P0.05,P0.01)respectively. The expression of Bax were higher in the group treated by proscar than that of the model group(P0.01). The difference of Bcl-2/Bax in the groups treated by high-dose of yiqiyonglinchongji and treared by proscar were not significant(P0.05). Conclusions Promoting apoptosis was probably the mechanism of yijitonglinchongji treating BPH, Bcl-2 and Bax genes play an important role in the regulation of prostatic apopitosis.

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Available abstract

Objective To investigate the mechanism that yiqiyonglinchongji treats benign prostatic hyperlassia. Methods A total of 8 case of BPH, 24 case of BPH influenced by yiqiyonglinchongji and proscar were studied.The apoptosis status was detected by means of Immunohistochemistry. Resulsts The expression of Bcl-2 were higher in model group than that of the group treated by high-dose of yiqiyonglinchongji and proscar(P0.05,P0.01)respectively. The expression of Bax were higher in the group treated by proscar than that of the model group(P0.01). The difference of Bcl-2/Bax in the groups treated by high-dose of yiqiyonglinchongji and treared by proscar were not significant(P0.05). Conclusions Promoting apoptosis was probably the mechanism of yijitonglinchongji treating BPH, Bcl-2 and Bax genes play an important role in the regulation of prostatic apopitosis.

Key concepts: Medicine, Apoptosis, Immunohistochemistry, Mechanism (biology), Rat model, Significant difference, BAX Protein, Gene

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