Evaluation of antihypertensive effect of compound telmisartan tablet on essential hypertension by ambulatory blood pressure monitoring

AIM To evaluate the antihypertensive effects of telmisartan/ hydrochlorothiazide(HCTZ) combination in patients with mild-to-moderate essential hypertension by 24 h ambulatory blood pressure monitoring.METHODS Twenty-eight patients with mild-to-moderate essential hypertension were treated with a fixed dose combination of telmisartan 40 mg and HCTZ 12.5 mg,1-2 tablets,once daily for 8 wk.24 h ambulatory blood pressure monitoring(ABPM) was performed before and after treatment,the trough:peak ratio and smoothness index were calculated.RESULTS The mean systolic blood pressure(SBP) and diastolic blood pressure(DBP) in 24 h,day time and night time all had a significant reduction(P0.01).The blood pressure loads of SBP and DBP were decreased significantly also(P0.01).The trough:peak ratio of SBP was 62.4%,DBP was 65.6%,the smoothness index of SBP was 1.08±0.36,DBP was 1.13±0.22.CONCLUSION The compound telmisartan tablet is an effective and safe antihypertensive drug with satisfactory trough:peak ratio and smoothness index.