Evaluation of Antihypertensive Effect of Compound Telmisartan on Essential Hypertension by Ambulatory Blood Pressure Monitoring

Objective To evaluate the antihypertensive effects of telmisartan in patients with mild-to-moderate essential hypertension by 24 hour ambulatory blood pressure monitoring.Methods Thirty patients with mild-to-moderate essential hypertension were treated with telmisartan 80mg,once a day for 8 weeks.24 h ambulatory blood pressure monitoring(ABPM) was performed before and atfter treatment,the trough/peak ratio and smoothness index were calculated.Results The mean systolic blood pressure(SBP) and diastolic blood pressure(DBP) in 24 h,day time and night time all had a significant reduction(P0.01).The blood pressure loads of SBP and DBP were decreased significantly also(P0.01).The trough/peak ratio of SBP was 63.2%,DBP was 65.8%.Conclusion The compound telmisartan is an effective and safe antihypertensive drug with satisfactory trough/peak ratio and smoothness index.