Clinical observation of effect on Huangkui Capsule combined with Losartan in treating proteinuria after renal transplantation

Objective To investigate the clinical effect of Huangkui Capsule combined with Losartan in treating proteinuria after renal transplantation.Methods 80 patients who accepted cadaveric renal transplantation more than six months and whose urinary protein ≥300 mg were randomly divided into treatment group(40 cases) and control group(40 cases).Treatment group was given 5 pills of Huangkui Capsules,3 times a day and Losartan 50 mg,once a day.While control group was given only Losartan 50 mg,once a day.The course of treatment was 8 weeks.24 h urinary protein,albumin,renal function,levels were measured before and after treatment,differences within groups and between groups were compared and clinical effect were evaluated.Results The total effective rate of treatment group was better than control group,there were statistically significant differences(P 0.05);after 8 weeks,urinary albumin and serum albumin in treatment group dropped significantly,there were statistically significant differences(P 0.05) when compared with control group.All results measured in different time within treatment group were statistically significant different(all P 0.05).Conclusion It is safe and effective of the combined treatment of Huangkui Capsule and Losartan in proteinuria after renal transplantation and worthy of clinical use.