Expression of Runx3 and Bcl-2 in Gastric Adenocarcinoma and Its Relation with Prognostic

Objective To investigate the expression of tumor suppressor gene Runx3 and the control apoptosis factor Bcl-2 in gastric adenocarcinoma,and its prognostic significance. Methods By using immunohistochemistry SP method the protein expressions of Runx3 and Bcl -2 was studied in 63 cases of gastric cancer,19 cases of low-level intraepithelial neoplasia tissue and 10 cases of normal gastric mucosa,specimens were obtained from patients who underwent partial gastric resection of benign lesions. Their relationship relating with clinic-pathological features and survival was also analyzed. Results The positive rate of Runx3 protein in gastric cancer was 39.7% which was significantly lower than that in the gastric nontypical hyperplasia tissue (21.1%) and normal gastric mucosa (10%),and there is a statistical difference (P0.05) among them,which showed the close correlation between the protein expression of Runx3 and histological type ,invasive depth and tumor node metastasis. The positive rate of Bcl-2 protein in gastric cancer was 65.1%,which was significantly higher than in gastric low-level intraepithelial neoplasia tissue(68.4%) and normal gastric mucosa(90%). There was no intimate correlation among the expression of Bcl-2 and invasive depth,TNM stages and tumor node metastasis. The Kaplan-Meier survival analysis showed that the survival rate of positive Runx3 was better than that in the negative groups (P0.01). Conclusion The high expression of Runx3 and the low expression of Bcl-2 protein may play an important role in the carcinogenesis and progression of gastric cancer. The detection of the two protein has a definite value in judging prognosis of gastric cancer.