Distribution of bacteriologic etiology and bacterial resistance in elder patients with lower respiratory tract infection

Objective To investigate the distribution of the bacteriologic etiology and bac terial resistance of clinical i-solates for the guidance of rational use of antibiotics. Methods Antimicrobial susceptibility to isolates from the sputum specimen of patients from 2000-2003 were analysed retrospectively. The statistical analysis were manipulated by SPSS. Results For all patients together, the most frequently isolated bacteria were gram - negative bacilli ( 68. 4% ) ,followed by gram - positive cocci (22.4%) and fungi (9.2%). In elder patients with lower respiratory tract infection, pseudomonas aeruginosa was the most important pathogeny and suscepitible to imipenem, cefepime, amikacin, cefoperazone -sulbactam and piperacillin. The resistant rates of gram - positive cocci to cefazolin,erythromycin and oxacillin were 63. 6% -77. 8% , 72. 7% - 88. 9% and 72.7% - 88.9% . However,all of the Gram - posit ive cocci were susceptible to vancomycin. Conclusion Gram - negative bacilli is the most significant pathogenic bacteria in elder patients with lower respiratory tract infection and the infection rate of pseudomonas aeruginosa is outstandingly high. On the other hand, the infec tion of gram - positive cocci and fungi would not be neglected.