Study on the effect of micro-ecologial agents in the intestinal flora and endotoxin level of patients with liver cirrhosis

Objective To investigate the effect of micro-ecological agents on the intestinal flora and endotoxin level of patients with liver cirrhosis.Methods 57 patients with liver cirrhosis and 24 healthy participants were chosen.57 patients with cirrhosis were randomly divided into control group(25 cases) and treatment group(32 cases),both groups were treated with conventional diuretic liver,the treatment group was added bifidobacterium triple viable capsule for 8 weeks.10 colonies number and endotoxin levels were measured in three groups pre and post treatment.Results Endotoxin levels in cirrhotic patients was significant higher than healthy group(P0.01),the colonies number of bifidobacteria,Lactobacillus and enterobacteriaceae in the intestinal flora were significant lower than healthy group(P0.05 or 0.01),the colonies number of staphylococcus aureus and Fusobacterium was significant higher than healthy group before treatment(P0.01).Endotoxin levels and the number of colonies of intestinal flora was no significant difference before treatment(P0.05),there was no significant difference of the levels of endotoxin in the control group after treatment(P0.05),while the level of Endotoxin in the treatment group was significantly lower(P0.01);the level of Enterobacteriaceae and Eubacterium was significant lower in control group(P0.05 or 0.01),the level of Bifidobacterium,Lactobacillus and Eubacterium increased significantly,staphylococci were significant lower in treatment group(P0.05 or 0.01),while the colony count of Bifidobacterium and Lactobacillus bacteria were significant larger in treatment group(P0.05 or 0.01).The complication rate of the treatment group were significantly lower after treatment comparing to before treatment(P0.01),no change was found in control group.Conclusion Micro-ecological agents can effectively regulate the condition of intestinal flora,enhancing the content of beneficial bacterium,such as bifidobacteria,declining the level of endotoxin,and exert considerable clinical significance in hepatocirrhosis treatment in bringing down the incidence of complication and improving the prognosis.