2002•Journal of Wenzhou Medical CollegeRequires access
Influence of losartan on collagen following myocardial ischemia in the rats
Zhang Huai
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Abstract
Objective:To investigate collagen changes following myocardial ischemia in the rats and the influence of losartan on them.Methods:The model of myocardial ischemia(MI) in the rats were copied and interfered with angiotensin Ⅱ type 1 receptor antagonist(AT1a) losartan(LT). Collagen amount was assessed by the method of chloramine T,so did Ⅰ/Ⅲ collagen ratio by immunohistochemical stain. The microstructure of myocardium was observed with electron microscope.Results:Collagen amount and Ⅰ/Ⅲ collagen ratio were increased significantly in the myocardial interstitium of group MI. However,those of group LT was reduced significantly than the group MI's.Conclusion:Losartan restrains collagen remodeling in the interstitium of myocardial ischemia.