Changes of serum IL-6 and sIL-2R levels in patients with idiopathic thrombocytopenic purpura and their clinical significance

Objective To study the changes and the clinical significance of serum IL-6 and sIL-2R levels in children with idiopathic thrombocytopenic purpura(ITP).Methods The levels of serum IL-6 and sIL-2R were measured in 37 ITP children with sandwich ELSIA as well as in 20 healthy children.At the same time,PAIb's qualitative determination was checked in 25 ITP children.And the relationships of PLT counts,IL-6 and sIL-2R's level in ITP children's peripheral blood were analyzed.Results The levels of ITP children's IL-6 and sIL-2R were significantly higher than those of control group(P0.01).The levels of IL-6 and sIL-2R were dramatically higher in the group of ITP children before treatment responsive to after treatment(P0.01).The levels of severe hemorrhage group's IL-6,sIL-2R were significantly higher than those of hyporrhea group's(P0.05).Nine of 25 ITP children's PAIb was completely positive(9/25),the levels of ITP children's IL-6,sIL-2R in completely positive group were significantly higher than non-positive group's(P0.05).The levels of ITP children's IL-6,sIL-2R(before treating)were negative correlation with PLT counts.The level between ITP children's IL-6 and sIL-2R was positive correlation.Conclusion PIL-6 and sIL-2R participate in ITP's procedure.The levels change with the pathogenetic condition and the course of disease.To sum up,cell mediated immunity plays a role in ITP's procedure as well as humoral-mediated immunity.