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2004•Chinese Journal of Gastroenterology and HepatologyRequires access

The effect of Genistein induction of apoptosis on gastric cancer cell SGC-7901

Wang Pi-long

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Abstract

Objective To study the inhibitory effects and apoptosis induction on human gastric cancer cell SGC-7901 by Genistein.Methods MTT, FCM and electron microscope were used to study the effects of Genistein on SGC-7901. Cell-immunochemistry were used to observe the change of C-myc, PCNA and Fas.Results MTT showed that the Genistein inhibited the growth of SGC-7901, and induced G 2/M cell cycle arrest, electron microscope showed that Genistein could induced cell apoptosis and necrosis, C-myc , PCNA expression were downregulated, and Fas expression were elevated.Conclusion Genistein can inhibit SGC-7901 cell growth via apoptosis induction and the arrest of cell cycle through many kinds of pathway.

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What this paper is about

Objective To study the inhibitory effects and apoptosis induction on human gastric cancer cell SGC-7901 by Genistein.Methods MTT, FCM and electron microscope were used to study the effects of Genistein on SGC-7901. Cell-immunochemistry were used to observe the change of C-myc, PCNA and Fas.Results MTT showed that the Genistein inhibited the growth of SGC-7901, and induced G 2/M cell cycle arrest, electron microscope showed that Genistein could induced cell apoptosis and necrosis, C-myc , PCNA expression were downregulated, and Fas expression were elevated.Conclusion Genistein can inhibit SGC-7901 cell growth via apoptosis induction and the arrest of cell cycle through many kinds of pathway.

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Available abstract

Objective To study the inhibitory effects and apoptosis induction on human gastric cancer cell SGC-7901 by Genistein.Methods MTT, FCM and electron microscope were used to study the effects of Genistein on SGC-7901. Cell-immunochemistry were used to observe the change of C-myc, PCNA and Fas.Results MTT showed that the Genistein inhibited the growth of SGC-7901, and induced G 2/M cell cycle arrest, electron microscope showed that Genistein could induced cell apoptosis and necrosis, C-myc , PCNA expression were downregulated, and Fas expression were elevated.Conclusion Genistein can inhibit SGC-7901 cell growth via apoptosis induction and the arrest of cell cycle through many kinds of pathway.

Key concepts: Genistein, Apoptosis, Cell cycle, Cell growth, MTT assay, Proliferating cell nuclear antigen, Cell, Chemistry

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