Therapeutical effects of Ulinastatin on systemic inflammatory response syndrome in the patients after thoracotomy

Objective To look for an efficient method to adjust the systemic inflammatory responses to prevent the patients with systemic inflammatory response syndrome(SIRS) after thoracotomy from changing into multiple organ dysfunction syndrome (MODS). Methods 30 post-thoracotomy patients with SIRS were randomly divided into regular treatment group (group B,n=15) and Ulinastatin treatment group (group A,n=15). Both groups were given regular treatment,while the group A were given Ulinastatin (100 000U,iv,Q8h,and continue to 5days) additionally. Temperature (T),heart rate (HR),respiration rate (RR) and white blood cell (WBC) were observed every day and the serum levels of CRP,TNF-alpha,IL-6 and IL-10 were measured before treatment,3 d,5 d and 7 d after treatment. Results All of the SIRS markers had no significant difference between group A and B before treatment. The serum levels of CRP,IL-6,TNF-alpha and the data of T,RR,HR and WBC were significantly reduced at the 3rd day after treatment in group A(P0.01). The above-mentioned indexes didn't reduce untill 5th day in group B,and the speeds were also slower than group A ( P 0.01). The serum levels of IL-10 increased significantly at the 5th day in group A (P0.05),but it didn't change at all the points in group B(P0.05). The duration of SIRS markers for more than 3days were fewer in group A than those in group B (χ 2=5.37,P 0.05),the incidence rates of MODS were also significantly lower than group B ( P 0.05). Conclusion The balances between anti-inflammatory response and inhibitory inflammatory response could be controlled by Ulinastatin efficiently,it could also prevent those patients from changing into MODS efficiently.