Diagnosis and treatment of intracranial infection in patients undergoing craniotomy

Objective To investigate the risk factors and treatment of intracranial infection in patients undergoing craniotomy.Methods 25 cases developed intracranial infection in 763 patients undergoing craniotomy were retrospective analysed.The risk factors of intracranial infection and its treatment were reviewed.Results 25 cases of patients with intracranial infection,vancomycin+ceftazidime treatment in 9 patients,the highest proportion of applications,was a better treatment method.Infratentorial craniotomy for intracranial infection was 8.7%,after supratentorial craniotomy,intracranial infection rate 2.5% (P0.05);Microsurgery of intracranial infection rate was 6.2%,non-microsurgery intracranial infection rate was 2.2% (P0.05);Operation duration of comparison,the operative time was divided into 3h,3～6h and 6h 3 groups,there were significant differences in pairwise comparison (P0.01 or P0.05);Intracranial drainage retention time comparison,divided into 3d,3～7d,7d 3 groups,there were significant differences in pairwise comparison (P0.01).Conclusion Microsurgery and infratentorial craniotomy,duration of operation,prolonged ventricular catheterization are the risk factors of intracranial infection.Empirical treatment for postsurgical intracranial infection appears to be very important according to our study.Antibacterials should be chosen with regard to the bacteria-sensitivity test.