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2008•China Practical MedicineRequires access

Dynamic changes of matrix metalloproteinses in atherosclerosis rabbit model

XU Zhao-ya

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Abstract

Objective To search the dynamic changes of the matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases-1(TIMP-1)of the atherosclerosis rabbit model.Methods Atherosclerosis models of rabbits were established through high lipid diet and injured femoral arteries by dilated balloon,and on day 1,7,14,21,28 after injured,MMP1,2,8,9 and TIMP-1 were detected with ELISA assay,then the curve reflecting the dynamic changes was draw,and the histopathology data was provided as well.Results The curve of dynamic changes MMP-1,9,and TIMP-1 were similar,the peaks were showed at 1 day after injured,and last for 7 days;there are relative among them;no obvious changes were showed in MMP-2,8.Conclusion The characteristic of dynamic changes of MMP-1,9 and TIMP-1 could provide evidence for search the vulnerable plaque.

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What this paper is about

Objective To search the dynamic changes of the matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases-1(TIMP-1)of the atherosclerosis rabbit model.Methods Atherosclerosis models of rabbits were established through high lipid diet and injured femoral arteries by dilated balloon,and on day 1,7,14,21,28 after injured,MMP1,2,8,9 and TIMP-1 were detected with ELISA assay,then the curve reflecting the dynamic changes was draw,and the histopathology data was provided as well.Results The curve of dynamic changes MMP-1,9,and TIMP-1 were similar,the peaks were showed at 1 day after injured,and last for 7 days;there are relative among them;no obvious changes were showed in MMP-2,8.Conclusion The characteristic of dynamic changes of MMP-1,9 and TIMP-1 could provide evidence for search the vulnerable plaque.

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Available abstract

Objective To search the dynamic changes of the matrix metalloproteinases(MMPs)and tissue inhibitors of metalloproteinases-1(TIMP-1)of the atherosclerosis rabbit model.Methods Atherosclerosis models of rabbits were established through high lipid diet and injured femoral arteries by dilated balloon,and on day 1,7,14,21,28 after injured,MMP1,2,8,9 and TIMP-1 were detected with ELISA assay,then the curve reflecting the dynamic changes was draw,and the histopathology data was provided as well.Results The curve of dynamic changes MMP-1,9,and TIMP-1 were similar,the peaks were showed at 1 day after injured,and last for 7 days;there are relative among them;no obvious changes were showed in MMP-2,8.Conclusion The characteristic of dynamic changes of MMP-1,9 and TIMP-1 could provide evidence for search the vulnerable plaque.

Key concepts: Medicine, Matrix metalloproteinase, MMP1, Histopathology, Pathology, Internal medicine, Cardiology, Biochemistry

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