2005•Acta Universitatis Medicinalis Secondae ShanghaiRequires access
Effect of B7-1 Costimulator Expression on Growth and Apoptosis of Lewis Lung Cancer
Zhiwei Chen, Huang Shaoguang, Meilin Liao, Wan Huan-ying
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Abstract
Objective To investigate the effect of B7-1 expression on growth and apoptosis of Lewis lung cancer (LLC). Methods Eighteen mice with Lewis lung cancer were divided into 3 groups: control, blank control vector and B7-1 group. Two weeks later, the expression rates of B7-1 and CD8 + were determined, and apoptotic index (AI) were calculated. Results The B7-1 molecules expression rate of B7-1 group was (46.6±5.7)%, and AI of B7-1 group (5.3±1.0)%. They were higher than other groups (P0.05). The percent of CD8 + cells in the blood and spleen of B7-1 group was (15.4±3.2)% and (41.8±21.8)%, respectively, which were higher than other groups (P0.05). The tumor suppress rate of B7-1 group was 34.6% and 87.0% at d 8 and d 14, respectively. Conclusion Increase in the B7-1 expression of tumor can not only suppress tumor growth and induce apoptosis, but also can enhance immunogenicity.