ScholarLens Back to search
2010•Chongqing yixueRequires access

Study on the expression of E-cadherin and β-catenin and its prognosis in medullary breast carcinoma

Tang Yong-xian

Open publisher page 0 citations

Abstract

Objective To investigate the clinical significance of E-cadherin and β-catenin expression in medullary breast carcinoma.Methods The immunohistochemical staining method was used to evaluate the positivity of E-cadherin and β-catenin in 49 cases medullary breast carcinoma.Results The positive rate of E-cadherin and β-catenin expression was higher in typical medullary breast carcinoma than in atypical medullary carcinoma,the expression of E-cadherin and β-catenin was verse relation(P0.05).The expression of E-cadherin andβ-catenin was correlated with lymph node metastasis and clinical stage(P0.05);it was not correlated with age,size of tumor and distant metastasis(P0.05).Conclusion Difference of E-cadherin and β-catenin expression is the important cause of different prognosis in medullary breast carcinoma.

About this research paper

What this paper is about

Objective To investigate the clinical significance of E-cadherin and β-catenin expression in medullary breast carcinoma.Methods The immunohistochemical staining method was used to evaluate the positivity of E-cadherin and β-catenin in 49 cases medullary breast carcinoma.Results The positive rate of E-cadherin and β-catenin expression was higher in typical medullary breast carcinoma than in atypical medullary carcinoma,the expression of E-cadherin and β-catenin was verse relation(P0.05).The expression of E-cadherin andβ-catenin was correlated with lymph node metastasis and clinical stage(P0.05);it was not correlated with age,size of tumor and distant metastasis(P0.05).Conclusion Difference of E-cadherin and β-catenin expression is the important cause of different prognosis in medullary breast carcinoma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the clinical significance of E-cadherin and β-catenin expression in medullary breast carcinoma.Methods The immunohistochemical staining method was used to evaluate the positivity of E-cadherin and β-catenin in 49 cases medullary breast carcinoma.Results The positive rate of E-cadherin and β-catenin expression was higher in typical medullary breast carcinoma than in atypical medullary carcinoma,the expression of E-cadherin and β-catenin was verse relation(P0.05).The expression of E-cadherin andβ-catenin was correlated with lymph node metastasis and clinical stage(P0.05);it was not correlated with age,size of tumor and distant metastasis(P0.05).Conclusion Difference of E-cadherin and β-catenin expression is the important cause of different prognosis in medullary breast carcinoma.

Key concepts: Medullary cavity, Cadherin, Catenin, Medullary carcinoma, Immunohistochemistry, Medicine, Breast carcinoma, Stage (stratigraphy)

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study on the expression of E-cadherin and β-catenin and its prognosis in medullary breast carcinoma — Research Paper | ScholarLens